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Starry, Starry Night, by Barry Jacobs and Casimir A. Fornal, Department of Psychology and Princeton Neuroscience Institute. Courtesy of the Princeton University Art of Science Competition.

Sometimes the connection between art and science is clear. When Barry Jacobs, a psychology professor at Princeton University, and Casimir Fornal, a research scholar, took a micrograph of a mouse’s hippocampus (shown above), they felt compelled to call it Starry, Starry Night, after the 1970s song by Don McLean about Vincent van Gogh. The dark, star-like bursts in the golden image are glial cells in the brain called astrocytes (“astro” meaning star in Greek).

A jury of photographers and scientists recently selected Starry, Starry Night and 42 other images for the 8th annual Art of Science exhibition at Princeton University. Each spring, the competition calls for Princeton students, faculty, staff and alumni to submit “images produced during the course of scientific research that have aesthetic merit.” This year, three winners selected by the jury, three people’s choice winners and 37 other works highlighted in the exhibition, currently on view at the Friend Center on Princeton’s campus, were chosen from an impressive lot of 170 entries hailing from 24 different university departments.

Worms and proteins, crystals and flames, even a compelling view of a fruit fly ovary are the subjects of the recent Art of Science images, which all in some way tie into this year’s theme: connections. “Some areas of research involve obvious ‘connections.’ Neural networks, for example, or the Internet. In other areas of research connections are more nuanced but just as valid. Fractal patterns in nature, the deterioration of architectural monuments due to the effects of acid rain, bridges, the wake that a jet of cool air generates as it passes through a hot flame, a qubit, the chemical signals than induce embryonic development,” according to the contest’s Web site.

In a statement released by the university, Adam Finkelstein, a computer science professor and one of the show’s organizers, expressed what he considers the strength of the Art of Science exhibition—its ability to create a new way of seeing for both artists and scientists. “At the same time,” said Finkelstein, “this striking imagery serves as a democratic window through which non-experts can appreciate the thrill of scientific discovery.”

Here is a selection from the exhibition:

East-West, West-East, by Martin Jucker. This image, which the jury named first place, depicts the east-west (shown in blue) and west-east (shown in red) winds that move around the globe. Courtesy of Princeton University Art of Science Competition.

Bridging the Gap, by Jason Wexler and Howard A. Stone, Department of Mechanical and Aerospace Engineering. This image, which earned the People’s Second Place, shows how negative pressure forms inside two drops of liquid (in blue), when those drops are between two transparent solids and viewed from above. Courtesy of the Princeton University Art of Science Competition.

C. instagram, by Meredith Wright ’13, Department of Molecular Biology (Murphy Lab). Wright snapped this photograph of C. elegans worms on an agar plate by holding her cellphone up to the eyepiece of her microscope. She calls it C. instagram because of the interest it sparked when she shared it on social media. Courtesy of the Princeton University Art of Science Competition.

Merger and Acquisition, by Daniel Quinn, Brian Rosenberg, Amanda DeGiorgi and Alexander Smits, Department of Mechanical and Aerospace Engineering. This image shows what happens to a drop of dye when it passes through still water. Courtesy of the Princeton University Art of Science Competition.

Crushed Birch, by Michael Kosk ’16, Woodrow Wilson School. The jury awarded this image of the cellular structure of a piece of birch second prize. Courtesy of Princeton University Art of Science Competition.

Messenger Meshwork, by Shawn C. Little, Kristina S. Sinsimer, Elizabeth R. Gavis and Eric F. Wieschaus, Department of Molecular Biology. Earning the People’s First Place, this image depicts four nurse cells in an egg chamber within a fruit fly’s ovary. Courtesy of the Princeton University Art of Science Competition.

Maze Dweller, by Chhaya Werner ’14, Department of Ecology and Evolutionary Biology. A goby fish peers through coral. Courtesy of the Princeton University Art of Science Competition.

Light Eddies, by Mitchell A. Nahmias and Paul R. Prucnal, Department of Electrical Engineering. This is a computer model of a laser that is designed to act like a neuron. Courtesy of the Princeton University Art of Science Competition.

Baby Mouse, by Celeste Nelson and Joe Tien, Department of Chemical and Biological Engineering. The vascular system of a baby mouse is shown here, in green, thanks to confocal imaging, which highlights the animal’s body with fluorescent light. Courtesy of the Princeton University Art of Science Competition.

A side view of Lathyrus odoratus L. 2009-2012. By Macoto Murayama. Image courtesy of Frantic Gallery.

The worlds of architecture and scientific illustration collided when Macoto Murayama was studying at Miyagi University in Japan. The two have a great deal in common, as far as the artist’s eye could see; both architectural plans and scientific illustrations are, as he puts it, “explanatory figures” with meticulous attention paid to detail. “An image of a thing presented with massive and various information is not just visually beautiful, it is also possible to catch an elaborate operation involved in the process of construction of this thing,” Murayama once said in an interview.

A front view of Lathyrus odoratus L. 2009-2012. By Macoto Murayama. Image courtesy of Frantic Gallery.

In a project he calls “Inorganic flora,” the 29-year-old Japanese artist diagrams flowers. He buys his specimens—sweetpeas (Lathyrus odoratus L. , Asiatic dayflowers (Commelina communis L.) and sulfur cosmos (Cosmos sulphureus Cav.), to name a few—from flower stands or collects them from the roadside. Murayama carefully dissects each flower, removing its petals, anther, stigma and ovaries with a scalpel. He studies the separate parts of the flower under a magnifying glass and then sketches and photographs them.

Using 3D computer graphics software, the artist then creates models of the full blossom as well as of the stigma, sepals and other parts of the bloom. He cleans up his composition in Photoshop and adds measurements and annotations in Illustrator, so that in the end, he has created nothing short of a botanical blueprint.

Cosmos sulphureus Cav., tubular flower, 2010. By Macoto Murayama. Image courtesy of Frantic Gallery.

“The transparency of this work refers not only to the lucid petals of a flower, but to the ambitious, romantic and utopian struggle of science to see and present the world as [a] transparent (completely seen, entirely grasped) object,” says Frantic Gallery, the Tokyo establishment that represents the artist, on its Web site.

Murayama chose flowers as his subject because they have interesting shapes and, unlike traditional architectural structures, they are organic. But, as he has said in an interview, “When I looked closer into a plant that I thought was organic, I found in its form and inner structure hidden mechanical and inorganic elements.” After dissecting it, he added, “My perception of a flower was completely changed.”

A side view of Commelina communis L. 2011. By Macoto Murayama. Image courtesy of Frantic Gallery.

His approach makes sense when you hear who Murayama counts among his influences—Yoshihiro Inomoto, a celebrated automotive illustrator, and Tomitaro Makino, an esteemed botanist and scientific illustrator.

Spoon & Tamago, a blog on Japanese design, says that the illustrations “look like they belong in a manual for semiconductors.” Certainly, by portraying his specimens in a manner that resembles blueprints, Murayama makes flowers, with all their intricacies, look like something human-made, something engineered.

Artist Heather Dewey-Hagborg and her DNA-derived self-portrait. Photo by Dan Phiffer.

It started with hair. Donning a pair of rubber gloves, Heather Dewey-Hagborg collected hairs from a public bathroom at Penn Station and placed them in plastic baggies for safe keeping. Then, her search expanded to include other types of forensic evidence. As the artist traverses her usual routes through New York City from her home in Brooklyn, down sidewalks onto city buses and subway cars—even into art museums—she gathers fingernails, cigarette butts and wads of discarded chewing gum.

At 12:15 pm on January 6, 2013, Dewey-Hagborg collected a cigarette butt (above, right) on Myrtle Avenue (above, left) in Brooklyn, NY. Testing the sample’s DNA revealed the smoker to be a male of Eastern European descent with brown eyes. Photos courtesy of Heather Dewey-Hagborg.

Do you get strange looks? I ask, in a recent phone conversation. “Sometimes,” says Dewey-Hagborg. “But New Yorkers are pretty used to people doing weird stuff.”

Dewey-Hagborg’s odd habit has a larger purpose. The 30-year-old PhD student, studying electronic arts at Rensselaer Polytechnic Institute in Troy, New York, extracts DNA from each piece of evidence she collects, focusing on specific genomic regions from her samples. She then sequences these regions and enters this data into a computer program, which churns out a model of the face of the person who left the hair, fingernail, cigarette or gum behind.

It gets creepier.

From those facial models, she then produces actual sculptures using a 3D printer. When she shows the series, called “Stranger Visions,” she hangs the life-sized portraits, like life masks, on gallery walls. Oftentimes, beside a portrait, is a Victorian-style wooden box with various compartments holding the original sample, data about it and a photograph of where it was found.

The portrait Dewey-Hagborg created based on the DNA sample from the cigarette butt collected on Myrtle Avenue. Image courtesy of Heather Dewey-Hagborg.

Rest assured, the artist has some limits when it comes to what she will pick up from the streets. Though they could be helpful to her process, Dewey-Hagborg refuses to swipe saliva samples and used condoms. She tells me she has had the most success with cigarette butts. “They [smokers] really get their gels into that filter of the cigarette butt,” she says. “There just tends to be more stuff there to actually pull the DNA from.”

Also on January 6, 2013, but at 12:20pm, Dewey-Hagborg collected this cigarette but (above, right) on the corner of Myrtle Avenue and Himrod Street (above, left) in Brooklyn. Testing revealed the smoker to be a female of European descent with brown eyes. Photos courtesy of Heather Dewey-Hagborg.

Dewey-Hagborg takes me step-by-step through her creative process. Once she collects a sample, she brings it to one of two labs—Genspace, a do-it-yourself biology lab in Brooklyn, or one on campus at Rensselaer Polytechnic Institute. (She splits her time between Brooklyn and upstate New York.) Early on in the project, the artist took a crash course in molecular biology at Genspace, a do-it-yourself biology lab in Brooklyn, where she learned about DNA extraction and a technique called polymerase chain reaction (PCR). She uses standard DNA extraction kits that she orders online to analyze the DNA in her samples.

If the sample is a wad of chewing gum, for example, she cuts a little piece off of it, then cuts that little piece into even smaller pieces. She puts the tiny pieces into a tube with chemicals, incubates it, puts it in a centrifuge and repeats, multiple times, until the chemicals successfully extract purified DNA. After that, Dewey-Hagborg runs a polymerase chain reaction on the DNA, amplifying specific regions of the genome that she’s targeted. She sends the mitochondrial amplified DNA (from both mitochondria and the cells’ nuclei) to a lab to get sequenced, and the lab returns about 400 base pair sequences of guanine, adenine, thymine and cytosine (G, A, T and C).

The artist produced this facial reconstruction from her DNA analysis of the cigarette butt she collected at Myrtle Avenue and Himrod Street. Image courtesy of Heather Dewey-Hagborg.

Dewey-Hagborg then compares the sequences returned with those found in human genome databases. Based on this comparison, she gathers information about the person’s ancestry, gender, eye color, propensity to be overweight and other traits related to facial morphology, such as the space between one’s eyes. “I have a list of about 40 or 50 different traits that I have either successfully analyzed or I am in the process of working on right now,” she says.

Dewey-Hagborg then enters these parameters into a computer program to create a 3D model of the person’s face.” Ancestry gives you most of the generic picture of what someone is going to tend to look like. Then, the other traits point towards modifications on that kind of generic portrait,” she explains. The artist ultimately sends a file of the 3D model to a 3D printer on the campus of her alma mater, New York University, so that it can be transformed into sculpture.

Five minutes later, at 12:25pm on January 6, 2013, Dewey-Hagborg obtained this piece of green chewing gum (above, right) on the corner of Wilson Avenue and Stanhope Street in Brooklyn. Testing revealed the chewer to be a male of Native American and South American descent with brown eyes. Photos courtesy of Heather Dewey-Hagborg.

There is, of course, no way of knowing how accurate Dewey-Hagborg’s sculptures are—since the samples are from anonymous individuals, a direct comparison cannot be made. Certainly, there are limitations to what is known about how genes are linked to specific facial features.”We are really just starting to learn about that information,” says Dewey-Hagborg. The artist has no way, for instance, to tell the age of a person based on their DNA. “For right now, the process creates basically a 25-year-old version of the person,” she says.

That said, the “Stranger Visions” project is a startling reminder of advances in both technology and genetics. “It came from this place of noticing that we are leaving genetic material everywhere,” says Dewey-Hagbog. “That, combined with the increasing accessibility to molecular biology and these techniques means that this kind of science fiction future is here now. It is available to us today. The question really is what are we going to do with that?”

The artist created this portrait based on the DNA in the chewed gum. Image courtesy of Heather Dewey-Hagborg.

Hal Brown, of Delaware’s medical examiner’s office, contacted the artist recently about a cold case. For the past 20 years, he has had the remains of an unidentified woman, and he wondered if the artist might be able to make a portrait of her—another clue that could lead investigators to an answer. Dewey-Hagborg is currently working on a sculpture from a DNA sample Brown provided.

“I have always had a love for detective stories, but never was part of one before. It has been an interesting turn for the art to take,” she says. “It is hard to say just yet where else it will take me.”

Dewey-Hagborg’s work will be on display at Rensselaer Polytechnic Institute on May 12. She is taking part in a policy discussion at the Wilson Center in Washington, D.C. on June 3 and will be giving a talk, with a pop-up exhibit, at Genspace in Brooklyn on June 13. The QF Gallery in East Hampton, Long Island, will be hosting an exhibit from June 29-July 13, as will the New York Public Library from January 7 to April 2, 2014.

Editor’s Note: After getting great feedback from our readers, we clarified how the artist analyzes the DNA from the samples she collects.

Terminal Mirage 2, 2003. Credit: David Maisel/INSTITUTE

For almost 30 years, David Maisel has been photographing areas of environmental degradation. He hires a local pilot to take him up in a four-seater Cessna, a type of plane he likens to an old Volkswagen beetle with wings, and then, anywhere from 500 to 11,000 feet in altitude, he cues the pilot to bank the plane. With a window propped open, Maisel snaps photographs of the clear-cut forests, strip mines or evaporation ponds below.

American Mine (Carlin NV 2), 2007. Credit: David Maisel/INSTITUTE

The resulting images are beautiful and, at the same, absolutely unnerving. What exactly are those blood-red stains? As a nod to the confusing state they place viewers in, Maisel calls his photographs black maps, borrowing from a poem of the same title by contemporary American poet Mark Strand. “Nothing will tell you / where you are,” writes Strand. “Each moment is a place / you’ve never been.”

The Mining Project (Butte MT 3), 1989. Credit: David Maisel/INSTITUTE

Maisel’s latest book, Black Maps: American Landscape and the Apocalyptic Sublime, is a retrospective of his career. It features more than 100 photographs from seven aerial projects he has worked on since 1985. Maisel began with what Julian Cox, the founding curator of photography at the Fine Arts Museums of San Francisco, calls in the book an “extensive investigation” of Bingham Canyon outside of Salt Lake City, Utah. His photographs capture the dramatic layers, gouges and textures of the open-pit mine, which holds the distinction of being the largest in the world.

This series expanded to include other mining sites in Arizona, New Mexico, Nevada and Montana, until eventually Maisel made the leap from black and white to color photography, capturing the bright chemical hues of cyanide-leaching fields in The Mining Project (a selection shown above). He also turned his lens to log flows in Maine’s rivers and lakes in a project called The Forest and the dried bed of California’s Owens Lake, drained to supply Los Angeles with water, in The Lake Project.

Oblivion, as the photographer describes on his personal Web site, was a “coda” to The Lake Project; for this series of black and white photographs, reversed like x-rays, Maisel made the tight network of streets and highways in Los Angeles his subject—see an example below. Then, in one of his most recent aerial endeavors, titled Terminal Mirage (top), he photographed the Mondrian-like evaporation ponds around Utah’s Great Salt Lake.

Oblivion 2N, 2004. Credit: David Maisel/INSTITUTE

All combined, Maisel’s body of work is what Cox calls “a medley of terrains transformed by humankind to serve its needs and desires.” The narrative thread, he adds in the introduction to Black Maps, is the photographer’s aim to convey humans’ “uneasy and conflicted relationship with nature.”

I wrote about Maisel’s photography for Smithsonian in 2008, when his “Black Maps” exhibition was touring the country, and at that time, the Long Island, New York-native hedged from being called an “environmental activist.” As Cox astutely notes, “The photographs do not tell a happy story,” and yet they also “do not assign any blame.” Maisel is attracted to these landscapes because of their brilliant colors, eye-catching compositions and the way they emote both beauty and danger.

The Lake Project 20, 2002. Credit: David Maisel/INSTITUTE

Maisel’s photographs are disorienting; it is a mental exercise just trying to orient oneself within the frame. Without providing solid ground for viewers to stand on, the images inevitably spark more questions than they do answers.

Each one is like a Rorschach test, in that the subject is, to some extent, what viewers make it to be. Blood vessels. Polished marble. Stained-glass windows. What is it that you see?

An exhibition of Maisel’s large-scale photographs, Black Maps: American Landscape and the Apocalyptic Sublime, is on view at the CU Art Museum, University of Colorado Boulder, through May 11, 2013. From there, the show will travel to the Scottsdale Museum of Contemporary Art in Scottsdale, Arizona, where it will be on display from June 1 to September 1, 2013.

ZnO Fall Flowers. Image by Audrey Forticaux, a graduate student in the Chemistry Department.

“The scientist does not study nature because it is useful; he studies it because he delights in it, and he delights in it because it is beautiful. If nature were not beautiful, it would not be worth knowing, and if nature were not worth knowing, life would not be worth living.”

—Jules Henri Poincare, a French mathematician (1854-1912)

Earlier this month, the University of Wisconsin-Madison announced the winners of its 2013 Cool Science Image contest. From an MRI of a monkey’s brain to the larva of a tropical caterpillar, a micrograph of the nerves in a zebrafish’s tail to another of the hairs on a leaf, this year’s crop is impressive—and one that certainly supports what Collage of Arts and Sciences believes at its very core. That is, that the boundary between art and science is often imperceptible.

Zebrafish neural network. Image by Pui-ying Lam, a graduate student studying cellular and molecular biology. A fluorescent molecule makes the neurons in the tail of a live zebrafish visible.

The Why Files, a weekly science news publication put out by the university, organizes the contest; it started three years ago as an offshoot of the Why Files’ popular “Cool Science Image” column. The competition rallies faculty, graduate and undergraduate students to submit the beautiful scientific imagery produced in their research.

Brain image. Image by Christopher Coe, a faculty member in the Psychology Department. This image of a monkey’s brain was created, thanks to an MRI technique called diffusion tensor imaging.

“The motivation was to provide a venue and greater exposure for some of the artful scientific imagery we encounter,” says Terry Devitt, the coordinator of the contest. “We see a lot of pictures that don’t get much traction beyond their scientific context and thought that was a shame, as the pictures are both beautiful and serve as an effective way to communicate science.”

Middle Earth. Image by Sheryl A. Rakowski, senior research specialist in the Bacteriology Department. Slime mold, which typically live as single-celled amoebae, create “flash mobs” when faced with a food shortage. These flash mobs meld into multicellular organisms.

Most of the time, these images are studied in a clinical context, Devitt explains. But, increasingly, museums, universities and photography contests are sharing them with the public. “There is an ongoing revolution in science imaging and there is the potential to see things that could never before be seen, let alone imaged in great detail,” says Devitt. “It is important that people have access to these pictures to learn more about science.”

Air Sea Interaction. Image by Rick Kohrs, senior instrument technician at the Space Science and Engineering Center. Superstorm Sandy is colliding with the East Coast of the United States in this image of water vapor and sea surface temperatures from October 28, 2012.

This year, the University of Wisconsin-Madison’s scientific community entered 104 photographs, micrographs, illustrations and videos to the Cool Science Image contest—a number that trumps last year’s participation by about 25 percent. The submissions are judged, quite fittingly, by a cross-disciplinary panel of eight scientists and artists. The ten winners receive small prizes (a $100 gift certificate to participating businesses in downtown Madison) and large format prints of their images.

Trichomes. Image by Emily Kief, undergraduate student, Botany Department. This scanning electron micrograph shows growths, or trichomes, on a leaf.

“When I see an image I love, I know the second I see it. I know it because it is beautiful,” says Ahna Skop, a judge and geneticist at the university. She admits she has a bias for images capturing nematode embryos and mitosis, her areas of expertise, but like many people, she also gravitates to images that remind her of something familiar. The scanning electron micrograph, shown at the top of this post, for example, depicts nanoflowers of zinc oxide. As the name “nanoflower” suggests, these chemical compounds form petals and flowers. Audrey Forticaux, a chemistry graduate student at UW-Madison, added artificial color to this black and white micrograph to highlight the rose-like shapes.

Hoodia. Image by Mo Fayyaz, distinguished faculty associate, Botany Department. A macroscopic view of the center of a hoodia flower—a succulent native to South Africa and Namibia.

Steve Ackerman, an atmospheric scientist at the university and a fellow judge, describes his approach: “I try to note my first response to the work—am I shocked, awed, baffled or annoyed?” He is bothered when he sees meteorological radar images that use the colors red and green to depict data, since they can be difficult for color blind people to read. “I jot down those first impressions and then try to figure out why I reacted that way,” he says.

Lunaria annua. Image by Kata Dosa, graduate student, Nelson Institute for Environmental Studies. The seeds of Lunaria annua can be seen through the plant’s translucent seed pods. In fact, you can even see the umbilical cord-like structure, called a funiculus, that connects the seed to the placenta.

After considering artistic qualities, and the gut reactions they trigger, the panel considers the technical elements of the entries, along with the science they convey. Skop looks for a certain crispness and clarity in winning images. The science at play within the frame also has to be unique, she says. If it is something that she has seen before, the image probably won’t pass muster.

Automeris banus. Image by Peggy Boone, graduate student, Zoology Department. This moth, in its larva form, stung Boone when she encountered it in Mexico’s Palenque National Park. Nonetheless, with a swollen hand, the field biologist managed to capture this photograph.

Skop hails from a family of artists. “My father was a sculptor and my mother a ceramicist and art teacher. All of my brothers and sisters are artists, yet I ended up a scientist,” she says. “I always tell people that genetically I’m an artist. But, there is no difference between the two.”

Beta catenin. Image by Vastal Mehta, research associate in the School of Veterinary Medicine’s Department of Comparative Biosciences. This micrograph shows a cluster of cells in a transgenic mouse, exhibiting high levels of beta catenin, a protein that plays a role in prostate development.

If anything, Skop adds, the winning entries in the Cool Science Image contest show that “nature is our art museum.”